Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: The common upregulated/downregulated differentially expressed genes(DEGs) identified among GSE15605, GSE3189.

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques:

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: Univariate and Multivariate Cox analysis of 13 candidate genes.

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques:

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: Expression levels of DLL3 and TUBB4A ( A,B ),“*” represents “p-value < 0.05”;Disease Free Survival(DFS) ( C,D ); Progress Free Interval (PFI) ( E,F ); Disease Specific Survival (DSS) ( G,H ).

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques: Expressing, Significance Assay

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: Immunohistochemistry images of TUBB4A in SKCM tissues and normal skin tissues from Human Protein Atlas ( A ). The results of RT-qPCR of TUBB4A expression levels in skin cutaneous melanoma cell lines ( B ). ***, **, and * represent significant differences between skin cutaneous melanoma cell lines and human primary normal skin melanocytes, respectively (P<0.001, P<0.01, P<0.05).

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques: Immunohistochemistry, Quantitative RT-PCR, Expressing

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: Prediction of miRNAs binding to TUBB4A.

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques: Binding Assay

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: Upstream potential miRNAs predicted to bind to TUBB4A. The miRNA-TUBB4A network ( A ). Overall survival (OS) of miRNAs in TCGA-SKCM cohort ( B ). The expression of TUBB4A and hsa-let-7b-5p in SKCM was negatively correlated ( C ). The expression of TUBB4A and hsa-miR-423-5p in SKCM was positively correlated ( D ).

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques: Expressing

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: The upstream lncRNAs of hsa-let-7b-5p in SKCM. The lncRNAs-hsa-let-7b-5p network ( A ). The expression levels of SNHG16 in skin cutaneous melanoma compared with TCGA normal and GTEx data controls ( B ), “*” represents “p-value < 0.05”. The expression of hsa-let-7b-5p and SNHG16 in SKCM was negatively correlated ( C ). The expression of TUBB4A and SNHG16 in SKCM was positively correlated ( D ).

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques: Expressing, Significance Assay

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: The co-expressed genes of TUBB4A in SKCM through UALCAN and GEPIA database ( A ). The top 8 enriched in biological process (BP), cellular component (CC), molecular function (MF)items for the co-expressed genes of TUBB4A ( B ). The top 8 enriched in KEGG for the co-expressed genes of TUBB4A ( C ).

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques:

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: The co-expressed genes of TUBB4A commonly appeared in UALCAN database and GEPIA database.

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques:

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: Correlation analysis. The expression of TUBB4A in SKCM was positively correlated with the expression of T cell CD4+ Th1 and T cell NK, respectively, by XCELL immune infiltration analysis.

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques: Expressing

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: Associations with Clinicopathologic Characteristics in SKCM Patients Using Cox Regression. C-index: 0.725(0.699-0.750).

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques:

Journal: Current Protein & Peptide Science

Article Title: Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma

doi: 10.2174/1389201023666220928120902

Figure Lengend Snippet: Diagnostic Value of TUBB4A Expression in SKCM. Forest plot of the multivariate Cox regression analysis in SKCM ( A ). A receiver operating characteristic (ROC) curve in SKCM between tumor and normal samples ( B ). A nomogram for predicting the probability of patients with 1-, 3- and 5-year overall survival (OS) ( C ). Calibration curve of the nomogram in 1-year,3-year and 5-year ( D-F ).

Article Snippet: TUBB4A protein was not expressed in normal skin tissue but had low and moderate expression in skin melanoma tissue from the Human Protein Atlas database.

Techniques: Diagnostic Assay, Expressing

Journal: International Journal of Medical Sciences

Article Title: Bioinformatics Analyses of Potential miRNA-mRNA Regulatory Axis in HBV-related Hepatocellular Carcinoma

doi: 10.7150/ijms.50126

Figure Lengend Snippet: Expression level and prognosis value of hub genes. (A) Protein expressions of hub genes were up regulated in HCC tissues. Images were taken from the Human Protein Atlas ( http://www.proteinatlas.org ) online database; (B) The mRNA expressions of hub genes were up regulated. Data were taken from the GEPIA database. (C) Kaplan-Meier analysis of hub genes for patients with HCC. Red boxes and grey boxes represent the mRNA levels of tumor and nomal tissue, respectively. * P < 0.05.

Article Snippet: Protein expressions of hub genes in normal and HCC tissues were analyzed in The Human Protein Atlas , .

Techniques: Expressing

Journal: bioRxiv

Article Title: A SNAI2-PEAK1 stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting a cytokine expression profile that converges on PI3K/Akt signaling

doi: 10.1101/2020.05.15.098772

Figure Lengend Snippet: a. Kaplan-Meier relapse-free survival (RFS) curves for patients with low or high PEAK1 transcript levels across all breast cancer subtypes (n = 1784). b. Kaplan-Meier RFS curves for HER2-positive breast cancer patients with low or high PEAK1 transcript levels (n = 272). c. PEAK1 transcript levels in normal breast stroma and breast cancer stroma across all subtypes (n = 6 and 53, respectively). d. PEAK1 transcript levels in breast cancer stroma of relapse-free patients and those with disease recurrence across all subtypes (n = 42 and 11, respectively). e. Expression correlation and linear regression analyses of PEAK1 and ETS1, KLF4, SNAI2, FN1, FOXC2 and MYC across patients having mixed or good outcomes (top, n = 45) and patients having poor outcomes (bottom, n = 8). f. Representative IHC images for HER2, PEAK1, SNAI2, MYC and FN1 in breast cancer tissue where PEAK1 expression in the stromal compartment is low (top) or high (bottom). g. Stromal IHC score correlation and linear regression analyses of PEAK1 and SNAI2, MYC and FN1 across six breast cancer tissue samples (patient #s 1874, 1939, 2428, 1920, 2392 and 3257). h. Average stromal IHC scores for PEAK1, SNAI2, MYC and FN1 in three HER2-negative patients and three HER2-positive patients. i-j. Kaplan-Meier overall survival (OS) curves for patients with low or high PEAK1 (h) or SNAI2 (i) transcript levels across all breast cancer subtypes (n = 1089). k-l. Kaplan-Meier OS curves for low or high PEAK1 transcript levels in breast cancer patients selected for low (j) or high (k) SNAI2 expression (n = 544). m. Kaplan-Meier RFS curves for low or high PEAK1 transcript levels in HER2-positive breast cancer patient selected for high SNAI2 expression (n = 75). * or ** indicates p-value < 0.05 or 0.01, respectively, as determined by a Student’s T-test.

Article Snippet: Immunohistochemical protein data from patient breast tumors are available in the Human Protein Atlas ( http://www.proteinatlas.org ).

Techniques: Expressing

Journal: Journal of Ovarian Research

Article Title: Identification of key genes and pathways related to cancer-associated fibroblasts in chemoresistance of ovarian cancer cells based on GEO and TCGA databases

doi: 10.1186/s13048-022-01003-2

Figure Lengend Snippet: The expression of 3 key genes in ovarian cancer tissues and high-grade serous ovarian cancer cells. A and B, IHC results of MYC in normal ovarian tissues ( A ) and cancer tissues ( B ) based on Human Protein Atlas data. C and D , IHC results of EGFR in normal ovarian tissues ( C ) and cancer tissues ( D ) based on Human Protein Atlas data. E and F , IHC results of CCND1 in normal ovarian tissues ( E ) and cancer tissues ( F ) based on Human Protein Atlas data. G - I Expression plots of MYC ( G ), EGFR ( H ), and CCND1 ( I ) in the platinum-sensitive ( n = 3) and platinum-resistant ( n = 3) high-grade serous ovarian cancer cell samples based on GEO microarray (GSE189717)

Article Snippet: C and D , IHC results of EGFR in normal ovarian tissues ( C ) and cancer tissues ( D ) based on Human Protein Atlas data.

Techniques: Expressing, Microarray